Uburyo bunoze bwo guhanura ibyago byindwara zifata imitsi

MyOme yerekanye amakuru yavuye ku cyapa cyabereye mu nama y’umuryango w’abanyamerika y’umuryango w’abantu (ASHG) yibanze ku manota y’ingaruka ziterwa na polygeneque (caIRS), ihuza genetiki n’impamvu gakondo z’amavuriro kugira ngo hamenyekane abantu bafite ibyago byinshi by’indwara zifata imitsi. (CAD) mubantu batandukanye.

Ibisubizo byerekanye ko caIRS zagaragaje neza abantu bafite ibyago byinshi byo kwandura indwara zifata imitsi, cyane cyane mu mipaka cyangwa hagati y’ibyago by’amavuriro ndetse no ku bantu bo muri Aziya yepfo.

Nk’uko bisanzwe, Akash Kumar, MD, PhD, umuyobozi mukuru w’ubuvuzi n’ubumenyi bwa MyOme, avuga ko ubusanzwe, ibikoresho byinshi n’ibizamini bya CAD byagerwaho byemejwe ku baturage bake.Igikoresho gikunze gukoreshwa cyane, indwara ya Atherosclerotic Cardiovascular Disease (ASCVD) Pooled Cohort Equation (PCE), ishingiye ku ngamba zisanzwe nk'urwego rwa cholesterol ndetse na diyabete kugira ngo hamenyekane ingaruka z'imyaka 10 CAD kandi ikanayobora ibyemezo bijyanye no gutangiza imiti ya statin, nk'uko Kumar yabitangaje. .

Ihuza amamiriyoni yimiterere yimiterere

Amanota y’ibyorezo byinshi (PRS), akusanya amamiriyoni y’imiterere y’imiterere y’ingaruka ntoya ku manota imwe, atanga amahirwe yo kurushaho kunoza neza ibikoresho byo gusuzuma ingaruka z’amavuriro, ”Kumar yakomeje.MyOme yateje imbere kandi yemeza amanota yingaruka zahujwe zihuza ibisekuruza bya PRS hamwe na caIRS.

Ibyingenzi byagaragaye mubiganiro byerekanaga ko caIRS yazamuye ivangura ugereranije na PCE mubice byose byemejwe hamwe nabasekuruza bapimwe.CaIRS yanagaragaje imanza zigera kuri 27 za CAD kubantu 1.000 mumipaka / hagati ya PCE.Byongeye kandi, abantu bo muri Aziya yepfo bagaragaje ubwiyongere bukabije mu ivangura.

Kumar yagize ati: "MyOme ifite amanota menshi ashobora guteza imbere gukumira no gucunga indwara mu buvuzi bw'ibanze mu kwerekana abantu bafite ibyago byinshi byo kwandura CAD, bashobora kuba barabuze."Ati: "Ikigaragara ni uko caIRS yagize uruhare runini mu kumenya abantu bo muri Aziya y'Epfo bafite ibyago byo kwandura CAD, ibyo bikaba ari ingenzi cyane kubera ko impfu zabo za CAD zigera hafi kuri ebyiri ugereranije n'Abanyaburayi."

Icyapa cya Myome cyiswe "Kwishyira hamwe kw'amanota ya Polygenic Risk hamwe na Clinical Factors Itezimbere Imyaka 10 yo Guhanura Ibyago Byindwara Yumutima."