Platelet ikomoka kubintu bikura byisesengura SEB-C100
Kumenyekanisha ibicuruzwa
Isesengura rya Platelet ryavuye mu isesengura ni igikoresho cyo gupima no gusesengura gishingiye ku buryo bwihariye bwo kwipimisha bwatangijwe na sosiyete yacu.Isesengura ryerekana ibintu bikura bikomoka kuri platel, ikimenyetso cya poroteyine yihariye mu nkari zabantu zakozwe iyo coronary arteri stenosis ibaye.Isesengura rirashobora kurangira muminota mike ukoresheje 1ml yinkari gusa.Isesengura rishobora kumenya niba imiyoboro y'amaraso ifite stenosisike hamwe n'urwego rwa stenosis kugira ngo itange ibisobanuro kugira ngo isuzumwe neza.Uburyo bwo gutahura no gusesengura uburyo bwo gukura bwa platelet bukomoka ku isesengura ni uburyo bwambere bwo kudashishoza butamenyekana, budasaba inshinge n’imiti ifasha, bikuraho ikibazo cyuko abantu allergique ziterwa na iyode irimo imiti idashobora kwandura CT nizindi coronari. arteri.Isesengura rifite ibyiza byo kugeragezwa gake, uburyo bwinshi bwo gukoresha, gukoresha byoroshye, kwihuta kwipimisha, nibindi, kandi ni ubwoko bushya bwa coronary arteri stenosis hakiri kare gutahura no gusuzuma.
Isesengura rifite ibyiza bikurikira:
1. Kwihuta: Shira inkari mubikoresho byerekana hanyuma utegereze iminota mike
2. Icyoroshye: Kwipimisha ntibiboneka mubitaro gusa.Birashobora kandi gukorerwa mubigo byisuzumisha kwa muganga, mu bigo byita ku bageze mu za bukuru cyangwa mu mibereho myiza y'abaturage
3. Ihumure: 1ml gusa yinkari zirakenewe nkicyitegererezo, nta maraso akuramo, nta muti, nta inshinge zinyuranye, nta mpungenge ziterwa na allergique
4. Ubwenge: Igenzura ryuzuye ryuzuye, rikora kubititabiriwe
5. Einstallation yoroshye: Ingano nto, irashobora gushyirwaho no gukoreshwa hamwe nigice cyameza
6. Kubungabunga byoroshye: Byikora bikurikirana kandi byerekana imiterere ikoreshwa kugirango bisimburwe byoroshye
Ihame ryibicuruzwa
Raman spectroscopy ikoresha urumuri rutatanye kugirango isesengure vuba imiterere ya molekile.Ubu buhanga bushingiye ku ihame rivuga ko iyo urumuri rutanga molekile, impanuka ya elastique ibaho kandi igice cyumucyo ukwirakwiza.Inshuro yumucyo utatanye iratandukanye ninshuro yumucyo wabaye, uzwi nka Raman ukwirakwiza.Ubukomezi bwa Raman butatanya bufitanye isano nimiterere ya molekile, bituma habaho gusesengura ubukana bwayo ninshuro kugirango umenye imiterere ya molekile n'imiterere neza.
Kubera ibimenyetso bya Raman bidakomeye no kwivanga kwa fluorescence kenshi, kubona Raman yerekanwe mugihe cyo gutahura birashobora kugorana.Kumenya neza ibimenyetso bya Raman biragoye rwose.Kubwibyo, ubuso bwazamuye Raman spectroscopy irashobora kongera cyane ubukana bwurumuri rwa Raman rwatatanye, rukemura ibyo bibazo.Ihame ryibanze rya tekinike ririmo gushyira ibintu bigomba kugaragara hejuru yicyuma cyihariye, nka feza cyangwa zahabu.kugirango rero ukore igicucu, nanometero-urwego rwubuso, bivamo ingaruka-yo kuzamura ingaruka.
Byerekanwe ko Raman yerekana ibintu byerekana imikurire ikomoka kuri platine (PDGF-BB) yagaragazaga impinga yihariye kuri cm 1509.Byongeye kandi, byagaragaye ko kuba hari ibimenyetso byerekana imikurire ikomoka ku maraso (PDGF-BB) mu nkari bifitanye isano na coronary arteri stenosis.
Ukoresheje Raman spectroscopy hamwe nubuhanga bwo kuzamura ubuso, isesengura rya PDGF rishobora gupima ko PDGF-BB ihari hamwe nimbaraga zayo ziranga inkari.Ibi bifasha kumenya niba imiyoboro y'amaraso ari stenotic hamwe n'urwego rwa stenosis, bityo bigatanga ishingiro ryo gusuzuma indwara.
Amavu n'amavuko y'ibicuruzwa
Mu myaka yashize, ubwiyongere bw'indwara z'umutima zigenda ziyongera buhoro buhoro bitewe n'imihindagurikire y'imirire n'imibereho, ndetse n'abaturage basaza.Umubare w'impfu zifitanye isano n'indwara z'umutima ziracyari hejuru cyane.Raporo y’ubuzima n’indwara z’Ubushinwa mu mwaka wa 2022, ivuga ko impfu z’indwara zifata umutima w’umutima mu baturage bo mu mijyi y’Abashinwa zizaba 126.91 / 100.000 na 135.88 / 100.000 mu baturage bo mu cyaro mu 2020. Iyi mibare yagiye yiyongera kuva mu mwaka wa 2012 n’ubwiyongere bugaragara. mu cyaro.Muri 2016, yarenze urwego rwumujyi kandi ikomeza kwiyongera muri 2020. Kugeza ubu, coronary arteriography nuburyo bwibanze bwo gusuzuma bwakoreshejwe mumavuriro kugirango hamenyekane indwara z'umutima.Nubwo byitwa "zahabu" yo gusuzuma indwara z'umutima, kutayitera hamwe nigiciro cyinshi byatumye habaho iterambere rya electrocardiografiya nkuburyo bwo kwisuzumisha buhoro buhoro.Nubwo isuzuma rya electrocardiogramu (ECG) ryoroshye, ryoroshye, kandi rihendutse, kwisuzumisha nabi no kutirengagiza indwara birashobora kugaragara, bigatuma bidashoboka ko hasuzumwa ivuriro ryindwara z'umutima.Kubwibyo, guteza imbere uburyo budatera, bworoshye cyane, kandi bwizewe bwo kumenya hakiri kare kandi byihuse indwara yumutima yumutima bifite akamaro kanini.
Ubuso bwongerewe imbaraga bwa Raman spectroscopy (SERS) bwabonye uburyo bukoreshwa mubumenyi bwubuzima bwo kumenya ibinyabuzima byitwa biomolecules ku gipimo gito cyane.Kurugero, Alula n'abandi.bashoboye kumenya umunota wa creinine mu nkari ukoresheje SERS spectroscopy hamwe nifoto catalitike ya silver nanoparticles irimo ibintu bya magneti.
Mu buryo nk'ubwo, Ma n'abandi.yakoresheje uburyo bwa magnetique buteranya nanoparticles muri SERS spectroscopy kugirango yerekane imbaraga nke cyane za acide deoxyribonucleic (ADN) muri bagiteri.
Iterambere rikomoka kuri platel-BB (PDGF-BB) rifite uruhare runini mu iterambere rya aterosklerose binyuze mu buryo bwinshi kandi rifitanye isano rya hafi n'indwara z'umutima.Enzyme ifitanye isano na immunosorbent assay (ELISA) nuburyo bwiganje bukoreshwa mubushakashatsi bwa PDGF-BB bwo kumenya iyi proteyine mumaraso.Urugero, Yuran Zeng na bagenzi be bagennye plasma yibanze ya PDGF-BB bakoresheje immunosorbent ifitanye isano na enzyme kandi basanga PDGF-BB igira uruhare runini mu gutera indwara ya aterosklerose ya karotide.Mu bushakashatsi bwacu, twabanje gusesengura SERS yerekana ibisubizo bitandukanye byamazi ya PDGF-BB hamwe nibitekerezo bike cyane, dukoresheje urubuga rwa 785 nm Raman spectroscopy.Twabonye ko impinga ziranga ihinduka Raman ya cm 1509 cm-1 zahawe igisubizo cyamazi ya PDGF-BB.Twongeyeho, twasanze iyi mpinga iranga nayo yari ifitanye isano nigisubizo cyamazi cya PDGF-BB.
Isosiyete yacu yafatanije nitsinda ryubushakashatsi bwa kaminuza gukora isesengura rya SERS spectroscopy ku byerekeranye ninkari 78 zose.Muri byo harimo ingero 20 z’abarwayi babazwe PCI, ingero 40 z’abarwayi batabazwe PCI, n’icyitegererezo 18 cy’abantu bafite ubuzima bwiza.Twasesenguye neza inkari SERS yerekanwe duhuza impinga ya Raman hamwe na Raman inshuro ya 1509cm-1, ifitanye isano na PDGF-BB.Ubushakashatsi bwerekanye ko ingero z’inkari z’abarwayi babazwe PCI zifite impanuka igaragara ya 1509cm-1, mu gihe iyi mpinga itari yabonetse mu nkari z’inkari z’abantu bafite ubuzima bwiza ndetse n’abarwayi benshi batari PCI.Muri icyo gihe, igihe amakuru y’ibitaro by’amavuriro ya coronary angiography yahujwe, hemejwe ko ubu buryo bwo gutahura buhuza neza no kumenya niba hari inzitizi zifata umutima n’umutima zirenga 70%.Byongeye kandi, ubu buryo bushobora kwisuzumisha hamwe na 85% na 87% bikurikiranye, urugero rwo guhagarika rurenga 70% mugihe cyindwara zifata imitsi yimitsi imenyekanisha impinga ziranga Raman ya cm 1509 cm-1.5% rero, ubu buryo buteganijwe kuba umusingi wingenzi muguhitamo niba abarwayi bafite indwara yimitsi yumutima bakeneye PCI, bitanga ubumenyi bwingirakamaro cyane kugirango hamenyekane hakiri kare abakekwaho indwara zifata imitsi.
Urebye aya mateka, isosiyete yacu yashyize mubikorwa ibyavuye mubushakashatsi bwambere twatangije Platelet Derived Growth Factor Analyser.Iki gikoresho kizahindura cyane kuzamura no gukoresha cyane indwara yumutima wa kare.Bizagira uruhare runini mu kuzamura ubuzima bwumutima wumutima mubushinwa ndetse no kwisi yose.
Bibliografiya
[1] Huinan Yang, Chengxing Shen, Xiaoshu Cai n'abandi.Kudasuzumwa no gutegereza indwara yumutima yumutima hamwe ninkari ukoresheje Raman spectroscopy yongerewe imbaraga [J].Isesengura, 2018, 143, 2235–2242.
Impapuro
| inomero yicyitegererezo | SEB-C100 |
| Ikizamini | Ubwinshi bwibintu bikura bya platel biranga impinga mu nkari |
| Uburyo bwo Kwipimisha | kwikora |
| Ururimi | Igishinwa |
| Ihame ryo gutahura | Raman spectroscopy |
| Imigaragarire | Micro USB Icyambu, Umuyoboro, WiFi |
| gusubiramo | Coefficient yo gutandukanya ibisubizo byikizamini ≤ 1.0% |
| urwego rw'ukuri | Ibisubizo bihuza neza nicyitegererezo cyagaciro gihuye. |
| ituze | Coefficient de variable ≤1.0% kuri sample imwe mugihe cyamasaha 8 uhereye kumashanyarazi |
| Uburyo bwo gufata amajwi | LCD yerekana, kubika amakuru ya FlashROM |
| igihe cyo gutahura | Igihe cyo gutahura icyitegererezo kimwe kiri munsi yamasegonda 120 |
| Imbaraga zakazi | adaptate power ： AC 100V ~ 240V ， 50 / 60Hz |
| ibipimo byo hanze | 700mm （L) * 560mm (W) * 400mm (H) |
| uburemere | Ibiro 75 |
| ibidukikije | ubushyuhe bwo gukora: 10 ℃ ～ 30 ℃;ugereranije n'ubushuhe: ≤ 90%;umuvuduko w'ikirere: 86kPa ～ 106kPa |
| Gutwara no kubika ibidukikije | ubushyuhe bwo gukora: -40 ℃ ～ 55 ℃;ugereranije n'ubushuhe: ≤95%;umuvuduko w'ikirere: 86kPa ～ 106kPa |
